In retinal vessels activation of the KATP channel dramatically increased the vasotoxicity of P2X7 receptor stimulation through elevation of calcium and increased oxidative stress (Shibata et al., 2018); such interactions may increase hypoxic challenge in glaucoma given the propensity of excess P2X7 receptor stimulation with elevated IOP (Mitchell et al., 2008). The gene discussed is P2RX7; the disease is glaucoma.