Recently, activated microglia were shown to induce reactive neurotoxic astrocytes by the release of interleukin-1 alpha (IL-1α), TNFα, and the classical complement component (C1q), and consequently drive RGC degeneration in the microbead glaucoma model (Liddelow et al., 2017; Guttenplan et al., 2020). Here, IL1A is linked to glaucoma.