AGER and Alzheimer disease: RAGE was discovered to promote additional Aβ accumulation by increasing the transportation of Aβ across the blood-brain barrier, in addition to acting as a receptor for Aβ protein and hence inducing Aβ-mediated microglial activation and consequent inflammation, which are linked to the pathogenesis of AD (Lue et al., 2001; Chaney et al., 2005).