INS and metabolic disease: Modern studies have found that ECD has beneficial weight loss, anti-inflammatory, and anti-oxidation effects, and significantly improves decreased insulin sensitivity (Zhang et al., 2017) and glucose and lipid metabolism disorders, especially lipid metabolism in metabolic diseases (Gao et al., 2015; Ding et al., 2018; Zhang et al., 2020b; Lee et al., 2020).