TLR2 and cardiovascular disorder: It restores intestinal barrier function (Desai et al., 2016) through the immunomodulatory effect of cell membrane protein AMUC-1100 binding to toll-like receptor 2 (Plovier et al., 2017) reducing macrophage infiltration, proinflammatory cytokines, and chemokine expression, therefore reducing the risk of cardiovascular disease (Li et al., 2016).