MAPT and Alzheimer disease: For example, recent studies demonstrated that AD hallmarks in plasma such as Aβ42/40, p-tau 181, and 217 can predict brain pathology with high accuracy, further adding evidence that they can be used as a non-invasive approach for the diagnosis and prognosis of AD (Nakamura et al., 2018; Karikari et al., 2020, 2021; Mattsson-Carlgren et al., 2020; Thijssen et al., 2020; Janelidze et al., 2021).