But more recent study has demonstrated that adding HHV-6 to the human neural cell cultures that simulated pathologies of AD led to Aβ-plaques and tau tangles accumulation after 2 days compared with the cultures without HHV-6 after cultures for 6 weeks (Eimer et al., 2018), hitting that HHV-6 infection-accelerated Aβ-plaques and tau tangles accumulation, the two main pathological features of AD. Here, MAPT is linked to Alzheimer disease.