IL6 and Cognitive impairment: Serum levels of pro-inflammatory cytokines/chemokines, including interleukin (IL)-6 (IL-6), CXCL2, and IL-1β, were higher in cognitive-impaired patients with brain amyloidosis than those without brain amyloidosis and controls; however, a significantly declined anti-inflammatory cytokine IL-10 was seen in the patients with brain amyloidosis compared with patients without brain amyloidosis (Cattaneo et al., 2017), implying pro-inflammatory cytokines/chemokines, contributing to brain amyloidosis and cognitive impairment.