Importantly, the hyperphosphorylation occurred at certain Tau epitopes that are strongly implicated in cytoskeletal dysfunction and synaptic loss (e.g., pSer262) (Callahan et al., 2002) and hippocampal atrophy (e.g., pThr231) (Hampel et al., 2005) in AD patients. The gene discussed is MAPT; the disease is Alzheimer disease.