APOE and Alzheimer disease: Of those that measured CSF Aß-42 concentrations, one community-based study of 1255 adults ranging from normal cognition, MCI, and AD reported no significant differences between AA and nHW after adjusting for age, sex, APOE-ε4 allele status, education, clinical status, body mass index (BMI), family history of AD, and CSF drift variables (Morris et al., 2019).