In another ADRC- and community-based study comprised of 135 participants with either normal cognition, MCI, or dementia, investigators found racial differences for both total- and phosphorylated-tau such that AA exhibited less burden than nHW (Howell et al., 2017); this difference persisted after adjustment for cognitive function, age, sex, APOE-ε4 allele status, ABCA7 risk allele status, Aß-42, hypertension, diabetes, and WMH volume. This evidence concerns the gene APOE and hypertensive disorder.