In an ADRC- and community-based sample comprised of 135 participants, investigators reported that CSF-derived NfL levels were lower in cognitively normal AA compared to nHW after adjustment for age, sex, APOE-ε4 allele status, ABCA7 risk allele status, Aß-42, hypertension, diabetes, and WMH volume (Howell et al., 2017). The gene discussed is NEFL; the disease is hypertensive disorder.