Other, more rare mutations, such as mutations in charged multivesicular body protein 2B (CHMP2B), Valosin-Containing Protein (VCP), ubiquilin 2 (UBQLN2), TANK-Binding Kinase 1 (TBK1), sequestosome 1 (SQSTM1), and T cell–restricted intracellular antigen 1 (TIA1) explain residual cases of genetic FTD (Pottier et al., 2016). The gene discussed is VCP; the disease is frontotemporal dementia.