The anti-inflammatory potential of strain DG was also evidenced in previous in vitro experiments since it was demonstrated to significantly reduce the activation of NF-κB in Caco-2 cells,47 and its administration in vivo significantly diminished inflammatory cytokine levels and increased mucosal IL-10 levels in ulcerative colitis patients upon rectal administration.48 Thus, L. paracasei DG preventive use may contribute to the alleviation of the excessive inflammatory response induced by SARS-CoV-2 infection. The gene discussed is NFKB1; the disease is ulcerative colitis.