Lastly, to determine how CHAF1A and MYCN expression correlate in primary tumor samples, we first inferred several CHAF1A gene signatures by overlapping the differentially regulated genes in SHEP cells (CHAF1A 96 h ON versus OFF) with CHAF1A‐correlated genes from cohorts 1 or 2 (CHAF1A OE + patient) and by overlapping the differentially regulated genes in IMR32 cells (CHAF1A KD1 day 5, CHAF1A KD2 day 10, CHAF1A KD3 day 5 and 10 common genes) with CHAF1A‐correlated genes from cohorts 1 or 2 (CHAF1A KD1–3 + patient). The gene discussed is MYCN; the disease is neoplasm.