We previously showed that high CHAF1A expression independently predicts poor outcome in patients with NB, and that loss of CHAF1A function promotes NB cell differentiation in vivo.[26] To determine how CHAF1A expression alters the NB phenotype, we expressed CHAF1A in SHEP cells using a Tet‐ON conditional system (Figure 1a). The gene discussed is CHAF1A; the disease is neuroblastoma.