MYCN and neuroblastoma: Neuronal cell proliferation and differentiation are two fundamental processes that determine cell fate.[53] In normal cell development, differentiation begins when cells exit the cell cycle.[54] Oncogenes disrupt that process by maintaining the cell cycle and blocking differentiation, leading to oncogenesis.[55] For example, the transcription factor MYCN acts as an oncogene in NB by blocking differentiation, maintaining pluripotency, and driving oncogenesis in mouse, zebrafish, and NCC‐derived models.[5, 6, 56]