Previous studies have shown that monoallelic deletion of the retinoid metabolism gene DHRS3, loss of the tumor suppressor NF1, and suppression of ZNF423, a transcriptional coactivator of the RA receptors, resulted in resistance to RA‐induced differentiation.[28, 29, 30] Here, to determine whether CHAF1A contributes to RA resistance in NB, we conditionally knocked down CHAF1A in RA‐resistant SK‐N‐AS cells[31] (Figure S3j, Supporting Information). The gene discussed is ZNF423; the disease is neuroblastoma.