CHAF1A and neuroblastoma: Ornithine decarboxylase (ODC1) is the rate‐limiting enzyme of polyamine synthesis.[44] CHAF1A expression in NB cells not only promotes ODC1 transcription but also significantly enhances ODC1 activity (p < 0.05; Figure 4h), suggesting that CHAF1A activates polyamine biosynthesis to sustain cell growth.