Studies have demonstrated that disrupted mitochondrial homeostasis caused by Drp-1 is related to many vascular disorders, such as endothelial dysfunctions, cardiac hypertrophy, heart failure, and so on, making Drp-1 as a potential therapeutic target in cardiovascular diseases (Jin et al. 2021; Sharp 2015). The gene discussed is DNM1L; the disease is cardiac hypertrophy.