IL36G and bacterial pneumonia: Whilst IL-36γ has been shown to have an anti-bacterial function in the lung in one model of bacterial pneumonia by driving protective type-1 responses and classical macrophage activation [38], in a second model involving Pseudomonas aeruginosa, IL-36γ induced the production of prostaglandin E2 (PGE2) and impaired bacterial clearance, possibility in a PGE2-dependent manner [39].