Downregulation of YAP/TAZ or c-Myc by inhibiting RhoA suppresses cystogenesis in a mouse autosomal dominant polycystic kidney disease model resulting from Pkd1 deficiency [49], and the G-protein-coupled receptor (GPCR) signaling could act through RhoA to regulate the Hippo-YAP pathway. This evidence concerns the gene GPBAR1 and autosomal dominant polycystic kidney disease.