To understand whether HSPD1 could be an attractive target for NSCLC, we performed a fitness analysis from a previously published dataset of a pan-cancer and genome-wide CRISPR/Cas9 screening of 18,009 genes, which included n = 21 adenocarcinoma (ADC) and n = 11 squamous cell carcinoma (SqCC) cell lines [35]. The gene discussed is HSPD1; the disease is adenocarcinoma.