The risk score of breast cancer prognosis was determined with the following formula: RiskScore = 0.629*ANO6 + 0.147*CELSR3 + 0.381*CLDN7+ 0.273*EPB41L4B-0.357*FAM166B -0.843*GPLD1–0.202*LEF1–0.202*PPARG -0.127*SUSD3. The gene discussed is CLDN7; the disease is breast cancer.