In summary, our work shows that EMX1 and EMX2 act as tumor suppressors by suppressing the activity of stem cell regulatory genes (OSKM, NANOG, and PROM1) and effectors of the canonical Wnt pathway (CTNNB1, TCF4, MYC, WNT1 and CCDN1) in sarcoma. Here, TCF4 is linked to sarcoma.