We found that A2ML1, CALB2, COL22A1, FCRL2, GPX3, HAND1, IDO1, LAMP5, MAP2, MMRN1, NKAIN4 and VAX2 were identified as cancer-promoting factors given their high expression correlation with shorter OS in patients with CRC. Here, COL22A1 is linked to colorectal carcinoma.