Considering the synaptic alterations after long periods of opioid exposure in the hippocampus, and the involvement of glial cells in opioid addictive behaviors, and regarding the GLT‐1 downregulation following chronic morphine administration, we aimed to investigate the role of the glutamate transporters of hippocampal glial cells in morphine dependence. The gene discussed is SLC1A2; the disease is morphine dependence.