In agreement with these findings, similar rescue effects of OGP (Y10A) were observed for asymmetric division (Figure 5G,H; Figure S4M, Supporting Information), mammosphere formation (Figure 5I,J; Figure S4N,O, Supporting Information), and chemosensitivity (Figure 5K,L; Figure S4P, Supporting Information) in tumor cells cocultured with CD10+GPR77+ CAFs in which CD10 was silenced. Here, C5AR2 is linked to neoplasm.