Epigenetic factors have also been shown to be involved in the regulation of autophagy.[11] H4K16ac is involved in the regulation of autophagic gene expression;[11, 12] and histone H1.2 has been shown to regulate autophagy in the diabetic retinopathy.[13] Small chemical inhibitors for epigenetic enzymes, such as BIX‐01294, an inhibitor of histone H3K9 methylation and 2‐PCPA, an inhibitor of H3K4 demethylase lysine demethylase 1A (KDM1A, also known as LSD1), have been shown to induce autophagy in mammalian cells,[14, 15, 16, 17] but the underlying mechanisms are not clear. This evidence concerns the gene KDM1A and diabetic retinopathy.