Here we described a novel observation that increased activated monocytes, T cells, and low A proliferation‐inducing ligand (APRIL) and B‐cell activating factor receptor (BAFFR) expressing B cells are present in COVID‐19 patients and also have sustained existence of these markers in convalescent plasma (COPLA) donors even after 3 weeks of recovery. The gene discussed is TNFRSF13C; the disease is COVID-19.