CALR and neoplasm: ICD is characterized by the extracellular secretion of high mobility group box 1 (HMGB1, a danger signal) and, exposure of calreticulin (CRT, eat‐me signal) on the cell surface which are classified as danger‐associated molecular patterns (DAMPs).[37, 38, 39] AIMS(PTX) treatment of 4T1 tumor cells induced extracellular release of HMGB1 which is characterized by ELISA (Figure 5b).