AIMS(EPT, R848, PTX) was effective in shifting a “cold tumor” to a “hot tumor” in that, 1) ICD was induced by AIMS(PTX)‐generated tumor‐associated antigen, 2) AIMS(EPT) eliminated the immune‐suppressive microenvironment by depleting immune‐suppressive cells (MDSCs and Treg cells) and decreasing the local concentrations of immune‐suppressive cytokines (TGF‐β and IL‐10), and 3) supra‐adjuvant increased infiltrating effector T cell counts in the TME (Figure 8). Here, TGFB1 is linked to neoplasm.