The successful analysis of PLAP expression in 12,381 cancers of 131 different tumor types and subtypes confirmed a high frequency of PLAP expression in testicular tumors but also showed that frequent and high‐level PLAP immunostaining occurs in various other tumor types, most commonly derived from the female genital tract, the gastroesophageal, and the pancreaticobiliary system. This evidence concerns the gene ALPP and cancer.