SHBG and male infertility: The genes associated with male infertility include genes involved in various processes like spermatogenesis (e.g. USP9Y, DBY, RBMY, TEX11, DAZ) (7–9), development of the male reproductive system (e.g. AR, FSHR, CFTR, ADGR2) (9, 10), steroid hormone signaling (e.g. SHBG) (11), etc. Defects in genes associated with male infertility manifest as either qualitative or quantitative sperm defects leading to infertility (12).