To functionally investigate the role of CXCR4 hyperactivation in the context of aggressive B-cell lymphoma, we chose the Eμ-Myc mouse model, which is characterized by B-cell-targeted overexpression of MYC, leading to MYC-driven aggressive B-cell lymphoma [31]. This evidence concerns the gene CXCR4 and B-cell non-Hodgkin lymphoma.