Furthermore, we performed RNA sequencing on CD19+ lymphoma cells from Eμ-Myc and Eμ-Myc;CXCR4C1013G and found that both groups displayed a highly similar transcriptome dominated by the MYC signature, with only eight pathways significantly altered in a gene set enrichment analysis (Supplementary Fig. S8a, b, c). The gene discussed is MYC; the disease is lymphoma.