Histopathology confirmed the aforementioned findings of the pre-malignant cohorts, and revealed that Eμ-Myc;CXCR4C1013G mice presented with a higher tendency toward extranodal disease, e.g., hepatic infiltration by lymphoma cells, further indicating a more invasive, extranodal phenotype of CXCR4 hyperactivated lymphoma (Fig. 4g and Supplementary Fig. S6e). Here, CXCR4 is linked to lymphoma.