For our study we selected somatic non-coding mutations in genomic regions marked as regulatory active by open chromatin (DNase1-HS), active promoters (H3K4me3) or enhancers (H3K4me1 and H3K27ac) or in conserved transcription factor binding sites (Supplementary Table S4) as defined in lymphoblastoid cell lines (LCLs) or in primary ALL cells24,25. Here, DNASE1 is linked to acute lymphoblastic leukemia.