The symptoms of anaphylaxis were scored by recording the sneezing times, nasal itching and nasal secretions of mice, as shown in Fig. 2A. Compared with the control group, the scores of AR group, AR + NC shRNA group, AR + TCONS_00147848 shRNA group and AR + TCONS_00147848 shRNA + FOSL2 OE group significantly increased (P < 0.01). Here, AR is linked to anaphylaxis.