TOX2 and neoplasm: Next, we check the accessibility of the REs containing TOX motif (Supplementary Fig. S13), in B cell subpopulations in both healthy and CLL donors and find the tumor-specific B cell subpopulation (B7) has much higher accessibility than the other B cell subpopulations, which supports the idea that specific expression of TOX2 induces a wide regulatory change (Fig. 5E).