As for specific mutations, five patients harbored four different CTNNB1 mutations, including p.T41I shared by all three tumor samples from P03, p.S45F shared in P07 and P10, p.S33C in P09, and p.S45F and p.K335T in LG-BilIN and GBC from P01, respectively. The gene discussed is CTNNB1; the disease is neoplasm.