CTNNB1 and adenoma: In our cohort, 5 of the 11 patients harbored CTNNB1 mutations; in 4 of these 5 cases, GBC and its adjacent LG-BilIN shared the same mutations in CTNNB1, suggesting that CTNNB1 mutations play a more active role in the formation of carcinoma in the context of adenoma/dysplasia than GBC alone.