Moreover, the infiltrations of CD11c+ DCs, CD3+CD4+, and CD3+CD8+ T cells in tumors of the ES-DSM + MW + CD39/anti-CRTα group were significantly decreased due to the deactivation of ATP and CRT (Supplementary Fig. 21), demonstrating that the ICD of tumor was critical during the tumor immunotherapy. The gene discussed is CALR; the disease is neoplasm.