We also demonstrated that increased expression of TCF4 leads to aberrant activity of the SEdistal regulating ENC1 expression in BC, thereby promoting the nuclear translocation of YAP1 and TAZ in the Hippo signaling pathway and the expression of the downstream anti-apoptotic genes Gli1, CTGF and FGF1 to enhance radio-resistance in BC cells (Fig. 8D). Here, CCN2 is linked to breast cancer.