While caspase-8 mutations occur most commonly in HNSCC (10%), they have also been reported in multiple other malignancies, including uterine (9.8%), stomach (4.8%), cervical (4.4%), colorectal (3.5%), melanoma (3.4%), and bladder (3.2%) cancers (TCGA, PanCancer Atlas [18]). Here, CASP8 is linked to melanoma.