Moreover, TET3 knocked-down cells under normoxia exhibited an identical alternative splicing pattern of ESRP1 targets (hMENA, SLK, SCRIB, RALGPS2, SLC37A2, FNIP1, CD44, and ARHGEF1) as the hypoxic breast cancer cells (Supplementary Fig. S4J), (Supplementary Table S1). This evidence concerns the gene ARHGEF1 and breast cancer.