Members of the tripartite motif (TRIM) family proteins are well known as E3 ubiquitin ligases which contain a conserved RING-finger domain, one or two B-boxes, and a coiled-coil domain.29 The TRIM family participates in various biological processes including fighting against HIV and tumor progression by modulating the K48- or K63-linked polyubiquitination to the targets. Here, TRAT1 is linked to neoplasm.