Significant variables in the univariate logistic regression (lymph node metastasis, PD-1 on TILs, PD-L1 on TILs, CD3, CD4, CD8, and FOXP3) were enrolled into the multivariate logistic regression model (online supplemental table 3). The gene discussed is CD8A; the disease is metastatic malignant neoplasm in the lymph nodes.