PNPO and type 1 diabetes mellitus: The enzyme pyridoxal 5′-phosphate synthase (K06215) involved in the deoxyxylulose 5-phosphate (DXP)-independent pathway for vitamin B6 synthesis, one pathway, five KO categories and six metaCyc reactions related to vitamin B12 (cobalamin) synthesis and five pathways, 11 KO categories and 13 MetaCyc reactions involved in SCFA synthesis, including pyruvate and acetyl-CoA production and butyrate synthesis from acetate or lactate, were decreased in women with T1D (Excel file E5-E7; Table 2; Fig. 5; Figure S11).