Collectively, RSL1D1 colocalizes with p53 and HDM2 in the nucleus of CRC cells and nucleolar stress does not affect the overall distribution and function of RSL1D1 as a regulator of p53 and HDM2, which probably contributes to the negative regulation of p53 by RSL1D1 under various conditions. This evidence concerns the gene MDM2 and colorectal carcinoma.