Crucially, RSL1D1 stabilizes HDM2 mRNA through protein-RNA interaction and also interacts with and recruits p53 to HDM2 to form a RSL1D1/HDM2/p53 protein complex, which enhances p53 ubiquitination and ultimately promotes the proliferation and survival of CRC cells. Here, RSL1D1 is linked to colorectal carcinoma.