In 2016, first to show effects and mechanism of E. ulmoides on rheumatoid arthritis (RA), ethanol extract (dose of raw herbs, 2.7 g/kg) of the cortex in collagen-induced arthritis (CIA) rats reduced the number of Th17-positive cells and downregulated serum IL-17 expression and increased the anti-inflammatory effects of IL-10. The gene discussed is IL10; the disease is rheumatoid arthritis.