INS and type 1 diabetes mellitus: All T1D patients were receiving exogenous insulin treatment, while all T2D patients were under metformin treatment: 16 were following metformin monotherapy, 13 were taking metformin together with a sulfonylurea drug and 10 associated incretin therapy to metformin (none were using thiazolidinediones or sodium-glucose co-transporter-2 inhibitors).