At that time, approximately 10 months of CAB consisting of leuprorelin acetate and bicalutamide had already reduced serum PSA from 11.8 ng/mL (September of 20XX-1) to < 0.01 ng/mL (August of 20XX), but cystoscopic findings clearly showed tumor invading the bladder neck. The gene discussed is KLK3; the disease is neoplasm.