Down syndrome (DS), a genetic disorder caused by trisomy of chromosome 21 (Ch21), is characterized by substantial developmental delay and intellectual disability during childhood and adulthood [1,2,3,4], which further deteriorate with the age-related onset of amyloid beta (Aβ) plaque and tau bearing neurofibrillary tangle (NFT) pathology similar to that observed in Alzheimer’s disease [5,6,7,8]. The gene discussed is MAPT; the disease is Dravet syndrome.