The CAD patients carrying the TNF-α-308A allele remained significantly related with the reduced risk for EDS (OR 0.64, 95% CI 0.41–0.99; p = 0.043) independent of age, sex, obesity, OSA severity and the circulating TNF-α levels in the multivariate model (Figure 3). The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.