TPO and rheumatoid arthritis: The authors profiled miRNAs in 8 ITP patients and 8 HCs before treatment, and after two, six and twelve weeks of treatment, and found that during TPO-RA treatment 14 out of 81 evaluated miRNAs showed significant changes, with two of them being increased in ITP (miRNA-33a-5p and miRNA-195-5p) and one of them being decreased in ITP (miRNA-199a-5p) compared to HCs prior to treatment [89].