FCGR2A and autoimmune thrombocytopenic purpura: Apart from the classical antibody Fc-FcγR-dependent platelet phagocytosis by macrophages, it has been suggested that Fc-independent platelet clearance may also be an important mechanism in ITP, which may occur via antibody-mediated loss of sialic acid from platelet glycoproteins, through hepatic Ashwell-Morell receptors [18].