Nevertheless, logistic regression analysis identified sPDGFRβ as crucial factor for HCC identification, obtaining the highest diagnostic value when combined with age, creatinine, and AFP levels, into the APAC score, able to outperform the GALAD score in any of the mentioned conditions, with particularly better diagnostic performance in patients with early-stage HCC (BCLC 0/A). The gene discussed is AFP; the disease is hepatocellular carcinoma.