The results obtained in our multi-etiological HCC cohort further validate such high diagnostic performance of the GALAD score, obtaining an AUC of 0.8995, with a sensitivity and specificity of, respectively, 81.2% and 85.5%, cut-off = −0.63, which outperformed the MELD score (AUC: 0.7956), ALBI score (AUC: 0.6896), and AFP levels (AUC: 0.8571). Here, AFP is linked to hepatocellular carcinoma.