FUS and amyotrophic lateral sclerosis: ALS occurs in two forms: (i) the sporadic form, which is the most common (90–95% of cases) and has no known hereditary component, and (ii) the family-type (5–10% of cases), which has a hereditary component involving altered genes such as C9orf72, FUS, SOD1, TARDBP, and KIF5A [8,9,10,11,12].