Since the role of SLC15A2 is related to the recovery of peptides [90] and neurotransmitters such as GABA and glutamate [91], and since the downregulation of glutamate transporters in astrocytes has been reported in ALS cases [92], it is evident the crucial role that an altered version of this gene has in the ALS onset. The gene discussed is SLC15A2; the disease is amyotrophic lateral sclerosis.