Especially, PAT increases pro-inflammatory stimuli and leads to oxidative stress by secreting multiple endocrine (e.g., leptin, resistin) and paracrine factors (e.g., tumor necrosis factor alpha (TNF-α), monocyte chemoattractant protein-1 (MCP-1), intercellular adhesion molecule 1 (ICAM-1) and interleukins (IL1, IL1β, IL-1Ra, IL-6, IL-8) in patients with CAD) [12,13]. Here, TNF is linked to coronary artery disorder.