There is evidence of a modulating effect of antidepressants on depression via the neurotrophins in preclinical and clinical models of depression; however, the results are conflicting; therefore, the therapeutic role of antidepressants cannot be clearly stated [21,22,34,35,36,37,38,39,40,41,42,43,44,45,46]. The gene discussed is BDNF; the disease is depressive symptom measurement.