CDH2 and gastric carcinoma: ADAM17 knockdown resulted, furthermore, in the downregulation of vimentin, Snail and N-cadherin and the upregulation of E-cadherin; in contrast, ADAM17 overexpression led to the upregulation of vimentin, Snail, N-cadherin and downregulation of E-cadherin, confirming that ADAM17 promotes EMT in gastric carcinoma cells [7].