CCN2 and renal fibrosis: Moreover, CTGF participates in the mechanism leading to TGF-induced FN expression in human lung epithelial cells [110]; in an experimental model represented by TGF-β-induced renal fibrosis in mice, this mechanism was inhibited, blocking MEK activity and so attenuating CTGF expression [111]; however, it remains unclear as to whether RSK1 and C/EBPβ are involved in TGF-β-induced CTGF expression in human lung epithelial cells and what is ADAM17’s role in EMT activation in the lung.