NLRP3 and cryopyrin-associated periodic syndrome: Omoyinmi et al. used a sensitive bioinformatics pipeline to determine low-level mosaicism (3%) for NLR family pyrin domain containing 3 (NLRP3) mutation in Cryopyrin-associated periodic syndrome (CAPS) patient and recommended manually checking the sequence alignment file (BAM) of the gene if mosaicism is suspected [54].