Indicated changes in some genes, e.g., Charcot-Leyden crystal protein (CLC, rs146776010), F-box and leucine-rich repeat protein 14 (FBXL14, rs117331652), DNA cross-link repair protein 1C (DCLRE1C, rs772438042) or NOTCH receptor 1 (NOTCH1, rs758642073), may have direct impact on immunology system and possible development of autoimmune disorder. The gene discussed is NOTCH1; the disease is Autoimmunity.