IL10 and colitis: Evolution course adapted host to tolerate commensals by different mechanisms, such as Treg induction and IL-10 secretion [151] and increasing knowledge allows/enables to develop new probiotic formulation which helps to reduce symptoms of colitis, downregulate expression of proinflammatory mediators such as IL-6 and TNFα and upregulate IL-10 mRNA level and the number of Treg [152].