BRCA2 and breast carcinoma: Most of the subjects enrolled in the study were high-risk women (128/150 = 85.33%); 44.00% (66/150) had proven BRCA1 or BRCA2 mutations, and 41.33% (62/150) had a family history of breast cancer which, together with other risk factors also including VBD, led to a lifetime risk for breast cancer of above 30%.